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I look forward to the first full week in October every year, as announcement of the Nobel prizes introduce me to some of the greatest accomplishments of humanity. For a moment, I can have a glimpse at the most impressive work in the sciences, literature, and human rights. The awardees - often recognised for work completed decades earlier - remind us of the immense body of effort behind the scenes that underpin the technologies we use every day. Last year’s winner of the prize in medicine, Katalin Karikó, was never granted tenure by the University of Pennsylvania, and yet she persisted.